QuickView for Neutrophil elastase;jsessionid=5DA7252A505008A652470C2A7877DAE1;jsessionid=7F11910C169C829510D02E42ED03440E (gene)

Gene Symbol:

Elane Mus musculus

Full name:

elastase, neutrophil expressed

Synonyms:

Ela2, F430011M15Rik, NE, neutrophil elastase, elastase 2, neutrophil, leukocyte elastase

Genomic Location:

Chr 10: 79349057-79350961

Description:

This gene encodes a member of the chymotrypsin-like family of serine protease enzymes that hydrolyzes a broad range of protein substrates including elastin. This gene is expressed by neutrophils where the encoded enzyme is stored in azurophil granules. Upon neutrophil activation, the active enzyme is released into the extracellular mileu. Mice lack...

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This gene encodes a member of the chymotrypsin-like family of serine protease enzymes that hydrolyzes a broad range of protein substrates including elastin. This gene is expressed by neutrophils where the encoded enzyme is stored in azurophil granules. Upon neutrophil activation, the active enzyme is released into the extracellular mileu. Mice lacking the encoded protein exhibit increased susceptibility to sepsis and death following intraperitoneal infection with Gram negative bacteria. This gene is located adjacent to a related proteinase gene on chromosome 10.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

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